Body Cells that Immune themselves from Death
Scientists have discovered such cells, which can cheat even their own death. The cells of the body usually kill themselves by exploding at the time of infection, so that the infection does not pass on to other cells. The cells of the body can die in many ways, but now scientists have claimed that there are also cells that can cheat their death.
Cells emit danger signals as they die
Dying cells release danger signals called cytokines. This process happens very fast, says bioengineer Gary Mo of the University of Illinois at Chicago. The cell inflates towards the balloon, sending out cytokines signals. After that it dies. Scientists used to believe that pyroptosis is a one-way process, but it is not so.
During a recent study, Gary Mo and his team found that cells also have an internal mechanism to reverse the one-way process of pyroptosis. Due to this the death of the cell is postponed for some time. Scientists claim that the cell can live for some more time by cheating its death. This study has been published in the journal Nature Communications.
Can Cancer Cells be destroyed?
From this study, scientists from Gary Mo and his team are now trying to find out how the process of pyroptosis can be reversed and whether it can kill cancer cells.
According to scientists, as soon as a cell receives a message that the process of pyroptosis has to start. Gasdermines, a special type of protein present inside it, gets activated. The microscopic particles of this protein make a bond with each other and make a hole in the outer layer of the cell. So that the inside parts of the cell come out of the hole. Gary Mo says that there is a pause button inside the cells to stop pyroptosis. which stops it.
In this way Cell Death is Averted
Gary Mo says that pyroptosis is a very complex process. To understand this process, the process of light responsive gasdermins protein was observed. The scientists found that they found an increase in calcium ions when they looked at the cells destroyed by pyroptosis. The amount of calcium is slightly higher around the outer layer of cells. But then he noticed that the hole made by the gasdermins in the cell has started closing and the flow of calcium has stopped.
The cell determines how many calcium ions it needs. As soon as she feels that the volume is increasing now, she closes the hole created by the gasdermines. That is, the process of pyroptosis stops. In a way, the death of the cell is averted. After this, near that weak hole, the cell makes a layer of fat. So that he can live for some time and this hole does not open.
Immunologist Isabella Roche of Oregon Health and Science University says that the closing of the hole made by a cell in its outer layer is astonishing. There are some elements that protect the cell from dying, which inhibit the process of pyroptosis.