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Palnat, the generic form of Palbociclib manufactured by Natco Pharma, is a pivotal medication in the treatment of hormone receptor-positive (HR+), HER2-negative breast cancer. As a second-generation cyclin-dependent kinase (CDK) 4/6 inhibitor, Palnat targets and inhibits the CDK4/6 proteins, which are crucial for cell cycle progression. By blocking these proteins, Palnat effectively slows down the proliferation of cancer cells, making it a cornerstone in managing advanced or metastatic HR+ breast cancer. Typically administered in combination with other therapies, such as aromatase inhibitors or fulvestrant, Palnat enhances the efficacy of treatment regimens. This combination approach allows for targeted therapy that specifically attacks cancerous cells while minimizing damage to healthy tissues. Palnat's affordability and accessibility make it a preferred choice for patients seeking effective treatment options for HR+ breast cancer.

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