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  • Southland Organics

    Southland Organics is an agriculture biotechnology company based in Athens, GA. We are a trusted manufacturer of organic soil conditioners, liquid fertilizer products and that stimulate plant growth as well as a line of bio catalyst products for rapi

  • Petrographypedia

    PetrographypediA is a portal of petrography. It provides an interactive atlas of thin-section photomicrograph analyses. It helps the process of petrographic description and analysis.

  • Post translational modification ubiquitination

    Ubiquitin is an about 8.5 kDa polypeptide consisting of 76 amino acids that is appended to the ?-NH2 of lysine in target proteins via the C-terminal glycine of ubiquitin.

  • Pyrophosphatase

    Pyrophosphatase (or inorganic pyrophosphatase) is an enzyme (EC that catalyzes the conversion of one molecule of pyrophosphate to two phosphate ions. This is a highly exergonic reaction.

  • Bioinformatics for Proteomics

    Proteins govern most biological processes and functions. Recently, much attention has been paid to study the entire protein sets available in a cell.

  • Chimeric Antigen Receptor

    Our novel Chimeric Antigen Receptor (CAR) technology platform consists of several key services including CAR construction, pseudoviral particles production and stable transduction.

  • Muromonab

    Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured.

  • Doxorubicin moa

    Doxorubicin, often regarded by the trade name “adriamycin”, is a member of the anthracycline compounds derived from Streptomyces peucetius var. caesius in the 1960s.

  • Akt inhibitor

    Ipatasertib, also known as GDC-0068, is a strong ATP-competitive pan-AKT inhibitor. It was initially derived during the screening and optimization process of a series of 6,7-dihydro-5H-cyclopenta[d]pyrimidine compounds.

  • Dhfr methotrexate

    Methotrexate, a folate analogue, was initially synthesized in the 1940s to serve as a dihydrofolate reductase (DHFR) inhibitor.

  • Linker peptide

    Peptide linkers belong to protease-sensitivity linkers (also called enzymatically cleavable linkers) that have gained significant attention in ADC development due to their superior plasma stability and controled payload release mechanism.

  • Cysteine maleimide

    Cysteine residues serve essential roles in protein structure and function due to their highly reactive thiol side chains that form inter or intra molecular di-sulfide bonds to enable correct protein folding. Thiol reactivity also provides an appealin

  • Adc payload

    Antibody-drug conjugates (ADCs) are next-generation targeted anti-tumor agents that are constructed by the covalent coupling of a monoclonal antibody with a cytotoxic payload drug via a small molecular linker. As a key factor in an ADC, the payload d

  • Duocarmycin adc

    Duocarmycins are a series of natural products originally isolated from Streptomyces bacteria in 1988. They exhibit an impressively high cytotoxicity and are subsequently developed into anti-tumor agents. Duocarmycin analogues, among which CC-1065.

  • Cleavable linker

    Linker design for ADCs is highly dependent on the biolology of the target cells, the characteristics of the antibody, and the structure of the drug molecule. Selection of the optimal linker is achieved through efficacy and toxicity assessments for ea

  • Ph sensitive linker

    pH-sensitive linkers (acid-labile linkers), are a class of chemically cleavable linkers that were first used in early ADC developments. Hydrazonesand cis-Aconityl is among the most widely used pH-sensitive linkers. A cis-aconityl linkage is offen use

This page was created on 15 Aug 2020 GMT v12.0