CJD uncommon noun 1. rare (usually fatal) brain disease (usually in middle age) caused by an unidentified slow virus; characterized by progressive dementia and gradual loss of muscle control SynonymsCreutzfeldt-Jakob diseaseJakob-Creutzfeldt disease Related words Broader terms brain disorder WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.