hypophysis hy·pop·hy·sis UK/haɪˈpɒ.fɪ.sɪs/ uncommon noun 1. the master gland of the endocrine system; located at the base of the brain Synonymspituitarypituitary glandpituitary body Related words Broader terms endocrine gland Parts diencephalon Part of hypophyseal stalkanterior pituitaryposterior pituitary WordNet 2.1 (Princeton University). Wiktionary (CC BY-SA). WordNet 2.1 Copyright Princeton University. All rights reserved.