senega se·nega uncommon dated noun 1. dried root of two plants of the genus Polygala containing an irritating saponin 2. perennial bushy herb of Central and southern United States having white flowers with green centers and often purple crest; similar to Seneca snakeroot SynonymsPolygala alba Related words Word family SenegalSenegaleseSenegalese francSenegal gumsenega rootsenega snakeroot Broader terms milkwortroot Parts Seneca snakeroot WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.