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The main types of immunotherapy can be broadly subdivided into non-antigen-specific and antigen-specific categories. Non-antigen-specific strategies include nonspecific immune stimulation and Immune checkpoint inhibitors,just contact [email protected]
Nivolumab, marketed as Opdivo, is a humanized IgG4 anti-PD-1 monoclonal antibody used to treat cancer. Nivolumab works as a checkpoint inhibitor, blocking a signal that would have prevented activated T cells from attacking the cancer, thus allowing.
Nepicastat hydrochloride (SYN117, RS-25560-197) is an inhibitor of dopamine beta-hydroxylase that catalyzes the conversion of dopamine to norepinephrine.
Peficitinib, also known as ASP015K and JNJ-54781532, is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats. ASP015K may have potential use in prevention of rejection in solid organ transplanta
Ca2+-ATPase is a monopeptide chain membrane integrin, which is a high affinity and low capacity Ca2+ efflux system. One or two Ca2+ molecules are pumped out of each hydrolyzed 1 molecule ATP, which mainly plays the role of steady-state sensitive fine
Anastrozole is an aromatase inhibitor that acts via binding competitively to the hem group of the CYP unit of the enzyme thereby reducing estrogen biosynthesis in the periphery and the breast. Anastrozole has little or no effect on other steroid horm
BOC Sciences has directed sincere efforts toward providing customers with top quality products designed for optimum flavoring and smell.
For customers convenience, we classify products on the basis of olfactive family. Besides, you can enter CAS,
The Ras superfamily of small GTPases is composed of more than 150 members, which share a conserved structure and biochemical properties, acting as binary molecular switches turned on by binding GTP and off by hydrolyzing GTP to GDP.
Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the recept
The MAPK signal pathway consists of three core kinases (MAP3K, MAPKK, and MAPK), with upstream (MAP4K) and downstream components (MAPKAPK). MAPK signaling pathway activation is performed by performing a conserved three-stage enzymatic cascade.
IL-1 is a cytokine produced by activated macrophages which mediates several physiological responses to infections and injuries, including stimulation of thymocyte proliferation, B-lymphocyte maturation and proliferation, induction of acute-phase prot
BOC Sciences advanced capabilities in carbohydrate synthetic area, purification and identification has benefited our customers in academia, research institutions, biotechnology and pharmaceutical at all stages of R&D from basic research to clinical
DNA encoded library (DEL) is a new screening platform commonly used to discover small-molecules that interfere with the activity of pharmaceutically relevant proteins. DNA-encoded chemical libraries are hybrid-type collections of combinatorial organi
Maxacalcitol and Impurities
Catalog Product Name CAS Number
Maxacalcitol Preform
Maxacalcitol 9-Hydroxy Iso Form
B1128-472711 Maxacalcitol Impurity B 132071-85-3
B1128-472710 Maxacalcitol 103909-75-7
B1128-112381 Maxacalcitol Intermediate.
BOC Sciences provides wide range of services such as custom radioisotope and stable isotope labeling to support your regulatory, development or research programs.
OX40(also called CD134) has OX40L, or CD252, as its ligand. Like CD27, OX40 promotes the expansion of effector and memory T cells, however it is also noted for its ability to suppress the differentiation and activity of T-regulatory cells, and also f
Teriparatidet is an effective anabolic (i.e., bone growing) agent used in the treatment of some forms of osteoporosis. It is also occasionally used off-label to speed fracture healing.
The first small molecule inhibitor of JNK to enter clinical trials was CC-401 (Celgene). A corporate press release dated February 5, 2003 stated CC-401, successfully completed a Phase I, double-blind, placebo controlled, ascending single intravenou
Several groups hypothesized that it may be necessary to construct ADCs with drugs of much higher molar potencies than conventional chemotherapeutics to achieve therapeutically effective levels of active drug within tumors in patients.
The screening libraries at BOC Sciences are made up of twenty-one libraries that can be used for drug discovery, laboratory drug screening, drug target identification, and other drug related applications. Each library can be screened individually or
Rapamycin is a mTOR inhibitor immunosuppressant and kinase inhibitor with both antifungal and antineoplastic properties. It selectively inhibits the transcriptional activation of cytokines.
WAY-316606 is a small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabolic agents for the treatment of osteoporosis or other bone-r
We have lots of compounds in stock, and our existing libraries of building blocks alongside with our specialized expertise allow short cut access to any desired novel nucleotide structure. In short, we are convinced that our custom nucleotides synthe
Vitamin D3 and Impurities
Catalog Product Name CAS Number
Vitamin D3 Caprate
Vitamin D3 Octanoate
B1960-485225 Alfacalcidol Impurity A 65445-14-9
B1960-485222 Calcifediol 19356-17-3
As a crucial cell signaling pathway in metazoan development, the Notch signaling pathway controls cell fate decisions in many different tissues in multicellular organisms. The Notch signaling pathway is composed of the Notch receptor, the Notch ligan
Hypoxia-inducible factor-1 (HIF-1) was first discovered by Semenza and Wang in 1992. Named after the hypoxia upregulation of erythropoietin (EPO) gene transcription. The structure of HIF-1 was subsequently established and the coding sequence of its c
The human CTLA4 gene is located in the long arm 33 band of chromosome 2 and contains four exons encoding the leader sequence, the ligand binding region, the transmembrane region, and the cytoplasmic tail region, respectively. CTLA4 has two subtypes.
Centromere-associated protein E (CENP-E) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region.
KIR, short for Killer-cell Immunoglobulin-like Receptor, is a receptor mainly expressed on the surface of natural killer (NK) cells and some T cells, which can recognize the major histocompatibility complex class I ?MHC-I? on the surface of target.
Early ADCs used clinically approved chemotherapeutic drugs because of their ready availability, amenability to chemical manipulation and their well known toxicological properties. https://www.bocsci.com/tag/adcs-cytotoxin-487.html
Our scientific team has established virtual compound database for different client-based projects with more than 2 million unique compounds, including ZINC, MDDR, ACD, NCI, etc. Just contact [email protected] for more information.
BOC Sciences provides wide range of services such as custom radioisotope and stable isotope labeling to support your regulatory, development or research programs.
Small-molecule modulators are a well-established class of potential useful drugs. Our products are included in all kinds of fields of Medical and Pharmaceutical research, such as Neurological Disease, Cancer, Metabolic Disease and so on.
PD-1, short for Programmed Death 1 (PD-1) receptor, a member of the B7 protein superfamily, is overexpressed on certain tumor cell types and on various tumor-infiltrating immune cells, and has two ligands, PD-L1 and PD-L2. An advantage of targeting P
Herceptin (Trastuzumab) is a monoclonal antibody drug for the treatment of breast cancer which is HER2 receptor positive. It acts via binding to HER2 receptor to suppress cell duplication.
T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a type 1 transmembrane protein containing an IgV extracellular domain and an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif followed by an immunoreceptor tyrosine-based inhibito
Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.It is currently approved for the treatment of rheumatoid arthritis (RA) in the United States.
Hsp90 uses a host of cochaperones which not only regulate the ATPase activity and conformational dynamics but which also mediate interactions with Hsp90 client proteins.
Description: Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. Molecular Formula C9H15N5O
Molecular Weight 209.25
Pre-formulation studies in combination with analytical methods are critical to identifying the best formulation strategy for a compound. Certain candidates present specific challenges such as poor solubility, low bioavailability and/or permeability.
Insulin signaling plays an important role in the physiological action of insulin. Insulin binds to its receptor, inducing intracellular signal transduction through a series of intracellular signaling molecules, activating signaling pathways, reaching
Cell adhesion molecules (CAMs) are molecules involved in the interaction between cells and extracellular matrix. CAM refers to the adhesion between cells, which is a form of information exchange between cells. CAM is a transmembrane glycoprotein.
The Hh signaling pathway is a highly compliant signaling pathway that plays an important role in many aspects. Especially, it plays a vital role in embryonic development and growth regulation, being morphogens, mitogens and organ development.
The active form of AMPK, i.e. phosphorylated AMP-activated protein kinase (p-AMPK), can down regulate the energy consuming process as well as increase adenosine triphosphate (ATP) generation through stimulating ATP-producing catabolic pathways.
cell immunoglobulin and mucin domain 3 (TIM3) is a member of Tim family, which consists of 301 amino acids. The common structure of TIM3 molecules includes: variable region of N-terminal immunoglobulin, mucin domain, transmembrane region and intracel
Various labeling techniques are developed in BOC Sciences such as enzymatic labeling, protein labeling, genetic labeling and quantum dot are widely utilized to meet our customers' need. Just contact [email protected] for more information.
Vitamin D2 and Impurities
Catalog Product Name CAS Number
Ergocalciferol Glucuronide
Ergocalciferol Sulfate
21343-40-8 25-Hydroxy-Ergocalciferol (25-(OH)-Vitamin D2) 21343-40-8
50-14-6 Vitamin D2 (Ergocalciferol) 50-14-6
BOC Sciences provides wide range of services such as custom radioisotope and stable isotope labeling to support your regulatory, development or research programs. As one of the worlds leading radiolabeling groups we have a reputation for excellence
VISTA also called Dies1 differentiation of embryonic stems cells 1 (Dies1), PD-1 homologous protein (PD-1H), belongs to the immunoglobulin family. The extracellular domain of VISTA is homologous to PD-L1. Human VISTA is mainly expressed in CD4+ cells
Vitamin D deficiency results in rickets, osteomalacia, osteoporosis, and is associated with multiple diseases including cancer, Alzheimer's disease, rheumatoid arthritis, diabetes, hypertension, glucose intolerance, and multiple sclerosis.
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