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Teriparatidet is an effective anabolic (i.e., bone growing) agent used in the treatment of some forms of osteoporosis. It is also occasionally used off-label to speed fracture healing.
The first small molecule inhibitor of JNK to enter clinical trials was CC-401 (Celgene). A corporate press release dated February 5, 2003 stated CC-401, successfully completed a Phase I, double-blind, placebo controlled, ascending single intravenou
Several groups hypothesized that it may be necessary to construct ADCs with drugs of much higher molar potencies than conventional chemotherapeutics to achieve therapeutically effective levels of active drug within tumors in patients.
The screening libraries at BOC Sciences are made up of twenty-one libraries that can be used for drug discovery, laboratory drug screening, drug target identification, and other drug related applications. Each library can be screened individually or
Rapamycin is a mTOR inhibitor immunosuppressant and kinase inhibitor with both antifungal and antineoplastic properties. It selectively inhibits the transcriptional activation of cytokines.
WAY-316606 is a small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. Modulators of the Wnt pathway have been proposed as anabolic agents for the treatment of osteoporosis or other bone-r
We have lots of compounds in stock, and our existing libraries of building blocks alongside with our specialized expertise allow short cut access to any desired novel nucleotide structure. In short, we are convinced that our custom nucleotides synthe
Vitamin D3 and Impurities
Catalog Product Name CAS Number
Vitamin D3 Caprate
Vitamin D3 Octanoate
B1960-485225 Alfacalcidol Impurity A 65445-14-9
B1960-485222 Calcifediol 19356-17-3
As a crucial cell signaling pathway in metazoan development, the Notch signaling pathway controls cell fate decisions in many different tissues in multicellular organisms. The Notch signaling pathway is composed of the Notch receptor, the Notch ligan
Hypoxia-inducible factor-1 (HIF-1) was first discovered by Semenza and Wang in 1992. Named after the hypoxia upregulation of erythropoietin (EPO) gene transcription. The structure of HIF-1 was subsequently established and the coding sequence of its c
The human CTLA4 gene is located in the long arm 33 band of chromosome 2 and contains four exons encoding the leader sequence, the ligand binding region, the transmembrane region, and the cytoplasmic tail region, respectively. CTLA4 has two subtypes.
Centromere-associated protein E (CENP-E) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region.
KIR, short for Killer-cell Immunoglobulin-like Receptor, is a receptor mainly expressed on the surface of natural killer (NK) cells and some T cells, which can recognize the major histocompatibility complex class I ?MHC-I? on the surface of target.
Early ADCs used clinically approved chemotherapeutic drugs because of their ready availability, amenability to chemical manipulation and their well known toxicological properties. https://www.bocsci.com/tag/adcs-cytotoxin-487.html
Our scientific team has established virtual compound database for different client-based projects with more than 2 million unique compounds, including ZINC, MDDR, ACD, NCI, etc. Just contact [email protected] for more information.
BOC Sciences provides wide range of services such as custom radioisotope and stable isotope labeling to support your regulatory, development or research programs.
The main types of immunotherapy can be broadly subdivided into non-antigen-specific and antigen-specific categories. Non-antigen-specific strategies include nonspecific immune stimulation and Immune checkpoint inhibitors,just contact [email protected]
Nivolumab, marketed as Opdivo, is a humanized IgG4 anti-PD-1 monoclonal antibody used to treat cancer. Nivolumab works as a checkpoint inhibitor, blocking a signal that would have prevented activated T cells from attacking the cancer, thus allowing.
Nepicastat hydrochloride (SYN117, RS-25560-197) is an inhibitor of dopamine beta-hydroxylase that catalyzes the conversion of dopamine to norepinephrine.
Peficitinib, also known as ASP015K and JNJ-54781532, is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats. ASP015K may have potential use in prevention of rejection in solid organ transplanta
Ca2+-ATPase is a monopeptide chain membrane integrin, which is a high affinity and low capacity Ca2+ efflux system. One or two Ca2+ molecules are pumped out of each hydrolyzed 1 molecule ATP, which mainly plays the role of steady-state sensitive fine
Anastrozole is an aromatase inhibitor that acts via binding competitively to the hem group of the CYP unit of the enzyme thereby reducing estrogen biosynthesis in the periphery and the breast. Anastrozole has little or no effect on other steroid horm
BOC Sciences has directed sincere efforts toward providing customers with top quality products designed for optimum flavoring and smell.
For customers convenience, we classify products on the basis of olfactive family. Besides, you can enter CAS,
The Ras superfamily of small GTPases is composed of more than 150 members, which share a conserved structure and biochemical properties, acting as binary molecular switches turned on by binding GTP and off by hydrolyzing GTP to GDP.
Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the recept
The MAPK signal pathway consists of three core kinases (MAP3K, MAPKK, and MAPK), with upstream (MAP4K) and downstream components (MAPKAPK). MAPK signaling pathway activation is performed by performing a conserved three-stage enzymatic cascade.
IL-1 is a cytokine produced by activated macrophages which mediates several physiological responses to infections and injuries, including stimulation of thymocyte proliferation, B-lymphocyte maturation and proliferation, induction of acute-phase prot
BOC Sciences advanced capabilities in carbohydrate synthetic area, purification and identification has benefited our customers in academia, research institutions, biotechnology and pharmaceutical at all stages of R&D from basic research to clinical
DNA encoded library (DEL) is a new screening platform commonly used to discover small-molecules that interfere with the activity of pharmaceutically relevant proteins. DNA-encoded chemical libraries are hybrid-type collections of combinatorial organi
Maxacalcitol and Impurities
Catalog Product Name CAS Number
Maxacalcitol Preform
Maxacalcitol 9-Hydroxy Iso Form
B1128-472711 Maxacalcitol Impurity B 132071-85-3
B1128-472710 Maxacalcitol 103909-75-7
B1128-112381 Maxacalcitol Intermediate.
BOC Sciences provides wide range of services such as custom radioisotope and stable isotope labeling to support your regulatory, development or research programs.
OX40(also called CD134) has OX40L, or CD252, as its ligand. Like CD27, OX40 promotes the expansion of effector and memory T cells, however it is also noted for its ability to suppress the differentiation and activity of T-regulatory cells, and also f
Vitamin D deficiency results in rickets, osteomalacia, osteoporosis, and is associated with multiple diseases including cancer, Alzheimer's disease, rheumatoid arthritis, diabetes, hypertension, glucose intolerance, and multiple sclerosis.
wo endothelin receptor subtypes have been isolated and identified, endothelin A receptor(ETA) and endothelin B receptor (ETB), and are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (GPCRA) which stimulate multipl
P-Menthane-3,8-diol, also called PARA-MENTHANE-3,8-DIOL, PMD, 1-(2-Hydroxy-4-methylcyclohexyl)-1-methylethanol,ect. Found in small quantities in the essential oil from the leaves of Corymbia citriodora.
MCC950, also called as CP-456773 or CRID3, is a small molecule that selectively inhibits activation of NLRP3 but does not inhibit NLRC4, AIM2, TLR2 signaling, or priming of NLRP3. MCC950 can be used to treat inflammatory diseases.
Pilaralisib is a Class 1 phosphatidylinositol 3 kinase (PI3K) family inhibitor. It is an orally bioavailable small molecule, targeting the class I PI3K family of lipid kinases. It is a pyrimidine derivatives compound discovered by Exelixis Inc.
Fatty acid amide hydrolase or FAAH (oleamide hydrolase, anandamide amidohydrolase) is a member of the serine hydrolase family of enzymes. FAAH is an integral membrane hydrolase with a single N-terminal transmembrane domain.
The maturing petroleum-based chemical industry, the pressures of environmental constraints and the explosive development of biotechnology have increased the interest in catalysis in enzymology. Just contact [email protected] for more information.
Ecamsule protect the skin from sunburn and erythema. It causes serious eye damage, so please wear protective gloves/protective clothing/eye protection/face protection.
ascular endothelial growth factor (VEGF), a specific mitogen isolated from endothelial cells by researchers in the late 20th century, has been shown to have the ability to induce physiological and pathological angiogenesis.
The p38 mitogen-activated protein kinase (p38MAPK) signaling pathway is a member of the mitogen-activated protein kinase (MAPK) family and is composed of MAPK kinase kinase, MAPK kinase and p38MAPK.
Epidermal growth factor (EGF) was first discovered in newborn rats in 1962. After about 20 years, the human epidermal growth factor receptor (EGFR) was isolated and purified. As research progresses, EGFR and its downstream pathways are constantly und
Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamins are principally involved in the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartm
Superparamagnetic iron oxide microbeads have broad applications in biomedicine, such as magnetic cell isolation and biomolecules purification, magnetic resonance imaging of diseased tissues, magnetic immunoassay, targeted delivery of drugs and antige
BOC Sciences X-ray crystallography service utilizes its experiences and proprietary technology to assist clients in employing X-ray crystallography characterisation in their drug discovery. Our services include crystallization screening, X-ray crys
BOC Sciences has assembled a world-class team of experts to bring extensive experience in diastereoselective and enantioselective synthesis at very large scale. We provide all the services, like asymmetric catalysis, chiral auxiliaries, biocatalysis.
BOC Sciences provides wide range of services such as custom radioisotope and stable isotope labeling to support your regulatory, development or research programs.
Small-molecule modulators are a well-established class of potential useful drugs. Our products are included in all kinds of fields of Medical and Pharmaceutical research, such as Neurological Disease, Cancer, Metabolic Disease and so on.
PD-1, short for Programmed Death 1 (PD-1) receptor, a member of the B7 protein superfamily, is overexpressed on certain tumor cell types and on various tumor-infiltrating immune cells, and has two ligands, PD-L1 and PD-L2. An advantage of targeting P
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