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Opioid Withdrawal Timeline Several factors determine the opioid withdrawal timeline: such as which opioids were being used, how frequently, your typical dose, and the length of substance misuse. Yet for most people, the following timeline can help you know what to expect: Eight Hours Since Last Use The symptoms of opioid withdrawal can occur as quickly as eight hours after opioids were last used. The first symptoms are typically mild and can include feeling irritable or chilly. 24 Hours Since Last Use Withdrawal symptoms begin to heighten after 24 hours, and include aches, racing heart rate, and sweating. At this stage, people begin to have difficulty sleeping as well, and experience powerful drug cravings. 72 Hours Since Last Use The third day of opioid withdrawal is typically the worst. People experience the full intensity of opioid withdrawal symptoms, possibly including diarrhea and vomiting.
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