Doxorubicin, often regarded by the trade name “adriamycin”, is a member of the anthracycline compounds derived from Streptomyces peucetius var. caesius in the 1960s.

Ipatasertib, also known as GDC-0068, is a strong ATP-competitive pan-AKT inhibitor. It was initially derived during the screening and optimization process of a series of 6,7-dihydro-5H-cyclopenta[d]pyrimidine compounds.

Methotrexate, a folate analogue, was initially synthesized in the 1940s to serve as a dihydrofolate reductase (DHFR) inhibitor.

Peptide linkers belong to protease-sensitivity linkers (also called enzymatically cleavable linkers) that have gained significant attention in ADC development due to their superior plasma stability and controled payload release mechanism.

Endothelial cells form the inner lining of a blood vessel and provides an anticoagulant barrier between the vessel wall and blood.

Our novel Chimeric Antigen Receptor (CAR) technology platform consists of several key services including CAR construction, pseudoviral particles production and stable transduction.

As a leading technology provider, Creative Biolabs has established a solid platform for offering a variety of CAR products. Our brilliant scientists can design tailor-made solutions to fit your exact needs.

A mAb’s epitope correlates with its functional activity. Biacore System is an attractive platform for epitope binning due to its speed and low antigen consumption. With strong expertise and the most advanced Biacore systems at hand, Creative Biolabs is ca

Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured.

Ubiquitin is an about 8.5 kDa polypeptide consisting of 76 amino acids that is appended to the ?-NH2 of lysine in target proteins via the C-terminal glycine of ubiquitin.

C1orf49 Full-Length MS Protein Standard (NP_115502), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency a

Human EGFR /ErbB1 Protein, Biotinylated (Biotinylated rhEGFR) Leu 25 - Ser 645, was labeled with biotin based on rhEGFR Protein, which was produced in human 293 cells (HEK293).

pH-sensitive linkers (acid-labile linkers), are a class of chemically cleavable linkers that were first used in early ADC developments. Hydrazonesand cis-Aconityl is among the most widely used pH-sensitive linkers. A cis-aconityl linkage is offen use

ADCs are next-generation precision medicines that target specific surface antigens and fight diseases by delivering cytotoxic payload drugs into the antigen-bearing cells. ADCs are trending in immunotherapy and are believed to have high potential and

Our scientists have developed the second and the third generation CAR products, which can enhance the persistence of CAR-T cells or -NK cells proliferation.

Amylomaltase (4-?-glucanotransferase; EC 2.4.1.25) catalyzes glucan transfer from one ?-1,4-glucan to another ?-1,4-glucan or to glucose.

Currently based in Ottawa, Ontario, Canada, Dr. Vazrick Nazari is an evolutionary biologist and entomologist. The University of Alberta awarded him an MSc in 2006 and the University of Guelph awarded him a Ph.D. in 2011. Among his main research areas are: Biogeography and systematization of lepidopteran species. Besides entomology, his interest in cultural entomology includes cultural anthropology. The importance of butterflies and moths to people throughout the world cannot be overstated. He began collecting and studying butterflies during this period of fascination with butterflies. Numerous articles of his have appeared in leading scientific journals, such as Science and Nature, and he continues to seek answers to questions that pique his curiosity. Vazrick advocates open access to science, and he consults for wildlife preservation organizations. As a way of coping with his mental illness, he enjoys helping people and volunteering for the homeless.

PetrographypediA is a portal of petrography. It provides an interactive atlas of thin-section photomicrograph analyses. It helps the process of petrographic description and analysis.

Cysteine residues serve essential roles in protein structure and function due to their highly reactive thiol side chains that form inter or intra molecular di-sulfide bonds to enable correct protein folding. Thiol reactivity also provides an appealin

Antibody-drug conjugates (ADCs) are next-generation targeted anti-tumor agents that are constructed by the covalent coupling of a monoclonal antibody with a cytotoxic payload drug via a small molecular linker. As a key factor in an ADC, the payload d

Duocarmycins are a series of natural products originally isolated from Streptomyces bacteria in 1988. They exhibit an impressively high cytotoxicity and are subsequently developed into anti-tumor agents. Duocarmycin analogues, among which CC-1065.

Linker design for ADCs is highly dependent on the biolology of the target cells, the characteristics of the antibody, and the structure of the drug molecule. Selection of the optimal linker is achieved through efficacy and toxicity assessments for ea

Tyrosinase (TYR) is the key enzyme regulating melanin production in hair and skin in humans. Although melanin displays maximal optical absorption at ultraviolet wavelengths, melanin has a broad spectrum of optical absorption with significant absorpti

Established from the bone marrow of a 31-year-old woman with acute myeloid leukemia (AML FAB M5a) at 2nd relapse; described to show strong lysozyme activity in the cytoplasm, phagocytic activities.

Pyrophosphatase (or inorganic pyrophosphatase) is an enzyme (EC 3.6.1.1) that catalyzes the conversion of one molecule of pyrophosphate to two phosphate ions. This is a highly exergonic reaction.

Creative Bioarray provides an extensive range of high quality RNA samples which are ideal for Northern blotting, ribonuclease protection assay, SI nuclease assay, RT-PCR/Q-PCR analysis.

A research paper, abstract or poster submitted to GSTF Journal of BioSciences (JBio) must be original that are unpublished and cannot be under review for publication elsewhere during the time it is being considered for GSTF Journal of BioSciences (JB

Without a doubt, a superior scFv leads to an even more superior CAR-T therapy. Creative Biolabs manifests as a world leading expert in antibody engineering field and provides our clients with the best scFv .

There are as many as 80 types of autoimmune diseases. Many of them have similar symptoms, which makes them very difficult to diagnose.

Our one-stop service covers all aspects from cell biology to animal tests with a special emphasis on the construction of tumor xenograft models.