PI3K (Phosphatidylinositol-4,5-bisphosphate 3-kinase) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

Parsatuzumab is a humanized monoclonal antibody designed for the treatment of cancers, especially the solid tumors. It acts as an immunomodulator and binds to EGFL7.

The carbonic anhydrases (or carbonate dehydratases) form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa).

Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamins are principally involved in the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartm

Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory amino acid transporter (EAAT)-2 is one of the major glutamate transporters expressed predominantly in astroglial cells and is responsible for 90% of total gl

Elastase is an enzyme that digests and degrades a number of proteins including elastin, an elastic substance in the lungs and some other organs that supports their structural framework. Elastase is specifically inhibited by alpha-1 antitrypsin.

Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins).

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Apoptosis refers to the autonomous, orderly programmed cell death of cells controlled by genes to maintain homeostasis, and plays an important role in maintaining intracellular homeostasis. There are three main apoptotic pathways.

Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the recept

OX40(also called CD134) has OX40L, or CD252, as its ligand. Like CD27, OX40 promotes the expansion of effector and memory T cells, however it is also noted for its ability to suppress the differentiation and activity of T-regulatory cells, and also f

B7-H3 is a type I transmembrane protein belonging to the B7 family of co-stimulatory proteins. B7-H3 is mostly expressed on professional APCs including B cells, macrophages, and dendritic cells at low levels. It is detected on various human and murin

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VISTA also called Dies1 differentiation of embryonic stems cells 1 (Dies1), PD-1 homologous protein (PD-1H), belongs to the immunoglobulin family. The extracellular domain of VISTA is homologous to PD-L1. Human VISTA is mainly expressed in CD4+ cells

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Ca2+-ATPase is a monopeptide chain membrane integrin, which is a high affinity and low capacity Ca2+ efflux system. One or two Ca2+ molecules are pumped out of each hydrolyzed 1 molecule ATP, which mainly plays the role of steady-state sensitive fine

Specific Calcitonin gene-related peptide (CGRP) receptors with Kd values varying from 15 to 260pM have been detected in human cerebellar cortex, rat brain and rat and porcine spinal cord including those of neuronal and peripheral origin.

Cannabinoid receptors are of a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains.

There are three recognised classes of carbonic anhydrase enzymes, alpha, beta and gamma, which have no significant sequence identity, and have structurally distinct overall folds. Yet, despite their structural differences.

Cell adhesion molecules (CAMs) are molecules involved in the interaction between cells and extracellular matrix. CAM refers to the adhesion between cells, which is a form of information exchange between cells. CAM is a transmembrane glycoprotein.

Bombesin receptors (nomenclature recommended by the NC-IUPHAR Subcommittee on bombesin receptors) are activated by the endogenous ligands gastrin-releasing peptide (GRP, P07492) (GRP), neuromedin B (NMB, P08949) (NMB) and GRP-(18-27) (GRP, P07492)