As a crucial cell signaling pathway in metazoan development, the Notch signaling pathway controls cell fate decisions in many different tissues in multicellular organisms. The Notch signaling pathway is composed of the Notch receptor, the Notch ligan

RO4929097, a small-molecule inhibitor of ? secretase (IC50= 4 nM, EC50= 5 nM), inhibits cellular processing of A?40 (EC50= 14 nM) and Notch(EC50= 5 nM). In vitro: Decreases the amount of A? peptides secreted into the culture medium in HEK293 cells (E

?-secretase maturation and its’ hardcore function in amyloidogenic pathway and notch pathway will be discussed below. Also, some inhibitors of ?-secretase, which appeal to the scientists, are expected to be potential drugs of AD and cancers induced