ERK protein kinase was isolated and identified in the early 1990s as a signal transduction protein that transmits mitogen signals. It is often found in the cytosol and is rapidly translocated into the nucleus of the cell when it is activated by mitog

The MAPK signal pathway consists of three core kinases (MAP3K, MAPKK, and MAPK), with upstream (MAP4K) and downstream components (MAPKAPK). MAPK signaling pathway activation is performed by performing a conserved three-stage enzymatic cascade.