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As one major component of an antibody-drug conjugate (ADC), the antibody is the key for target specificity and serves as the cargo to deliver the cytotoxic drug (payload). A payload drug can be attached to different sites on an antibody using diverse

Fleximers are different series of flexible, or "split,” purine base analogues designed to learn how nucleobase flexibility affects the recognition, binding, and activity of nucleoside (tide) analogues. There is a purine base scaffold in the fleximers. With this purine base scaffold, the imidazole and pyrimidine moieties are combined by a single carbon-carbon bond rather than being "fused,” as is typical for the purines. In previous reports, a number of novel fleximers have been screened, and these fleximers can combine the flex-base motif with the flexible acyclic sugar scaffold of the FDA-approved drug acyclovir (serves as a polymerase inhibitor). Studies have demonstrated that these fleximers can inhibit HCoV-NL63 and MERS-CoV replication in cell culture. However, it is still unknown how these novel analogues disrupt viral replication. In summary, acyclovir fleximers for SARS-CoV-2 are a group of promising drug candidates for the new drug discovery.

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Established by irradiation of the adherent cells in long-term bone marrow cultures derived from C3H/HeNSlc strain mice.

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Bone marrow cells are the cells contained within the bone marrow. These include stromal cells, which are not directly involved in haematopoiesis, and haematopoietic stem cells.

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References of how our cellular receptors function.

Established from the pleural effusion of a 65-year-old man with adenocarcinoma of the lung, typed as non-small cell lung carcinoma; matched EBV+ B-lymphoblastoid cell line (B-LCL) is available (HCC-78BL)

Cellulase is any of several enzymes produced chiefly by fungi, bacteria, and protozoans that catalyze cellulolysis, the decomposition of cellulose and of some related polysaccharides.

Peripheral blood cells are the cellular components of blood, consisting of erythrocytes, leucocytes and platelets, which are found within the circulating pool of blood.

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Infectious diseases cause an overwhelming number of deaths around the world and their clinical management is often hampered by the emergence of multidrug resistant strains. Therefore, prevention through vaccination is currently the best course of act

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3D models provide microenvironments which can more accurately reflect the natural environment inside of a living organism. Cells embedded in a 3D environment exhibit better intercellular interactions with more physiological responses.

Dulaglutide is a novel glucagon-like peptide-1 agonist (GLP-1) biologic drug consisting of a dipeptidyl peptidase-IV-protected GLP-1 analogue covalently linked to a human IgG4-Fc heavy chain by a small peptide linker.

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