cantaloup can·ta·loup uncommon noun 1. a variety of muskmelon vine having fruit with a tan rind and orange flesh Synonymscantaloupecantaloupe vineCucumis melo cantalupensis 2. the fruit of a cantaloup vine; small to medium-sized melon with yellowish flesh Synonymscantaloupe Related words Word family cantaloupecantaloupe vine Broader terms muskmelonsweet melon Parts cantaloupe WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.