capital of Chile ca·pi·ta·lofchile uncommon noun 1. the capital and largest city of Chile; located in central Chile; one of the largest cities in South America SynonymsGran SantiagoSantiagoSantiago de Chilecapital of Chile Related words Broader terms national capital Parts Chile WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.