eastern United States eas·ter·nu·nitedstates uncommon noun 1. the region of the United States lying north of the Ohio River and east of the Mississippi River SynonymsEasteastern United States Related words Broader terms geographical area Parts United States Part of SoutheastNortheastAllegheniesAppalachians WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.