Epistle to the Colossians epist·le·tot·hecolossians uncommon noun 1. a New Testament book containing an epistle from Saint Paul to the Colossians in ancient Phrygia SynonymsEpistle of Paul the Apostle to the ColossiansEpistle to the ColossiansColossians Related words Broader terms book Parts New Testament WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.