erythema nodosum eryt·he·ma·nodosum uncommon noun 1. skin condition characterized by tender red nodules on the shins and legs Synonymserythema nodosum Related words Word family erythema nodosum leprosum Broader terms erythema Narrower terms erythema nodosum leprosum WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.