herpes encephalitis her·pe·sen·cephalitis uncommon noun 1. common form of acute encephalitis caused by herpes simplex 1; usually affects the temporal and frontal lobes Synonymsherpes simplex encephalitisherpes encephalitisacute inclusion body encephalitis Related words Broader terms encephalitis WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.