hydroxyzine hydrochloride hyd·ro·xy·zinehydrochloride uncommon noun 1. a drug (trade names Atarax and Vistaril) used as a tranquilizer to treat anxiety and motion sickness Synonymshydroxyzine hydrochloridehydroxyzineAtaraxVistaril Related words Broader terms minor tranquilizer WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.