I Thessalonians it·hes·sa·lonians uncommon noun 1. a New Testament book containing Saint Paul''s first epistle to the Thessalonians SynonymsFirst Epistle of Paul the Apostle to the ThessalonFirst Epistle to the ThessaloniansI Thessalonians Related words Broader terms book Parts New Testament WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.