John Macleod john·mac·leod uncommon noun 1. Scottish physiologist who directed the research by F. G. Banting and C. H. Best that led to the discovery of insulin (1876-1935) SynonymsMacleodJohn MacleodJohn James Rickard Macleod Related words Broader terms physiologist WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.