Lou Gehrig lou·geh·rig uncommon noun 1. baseball player who died of amyotrophic lateral sclerosis (1903-1941) SynonymsGehrigLou GehrigHenry Louis Gehrig Related words Word family Lou Gehrig's disease Broader terms ballplayer WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.