malignant neoplasm ma·lig·nant·neoplasm uncommon noun 1. a tumor that is malignant and tends to spread to other parts of the body Synonymsmalignant tumormalignant neoplasmmetastatic tumor Related words Broader terms tumormalignancy Narrower terms carcinosarcomacancerangiosarcomamyelomaneuroblastomaneuroepitheliomaretinoblastoma WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.