Mother Seton mot·her·se·ton uncommon noun 1. United States religious leader who was the first person born in the United States to be canonized (1774-1821) SynonymsSetonElizabeth SetonSaint Elizabeth Ann Bayley SetonMother Seton Related words Broader terms religious leader WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.