multiple sclerosis mul·tip·lesc·lerosis uncommon noun 1. a chronic progressive nervous disorder involving loss of myelin sheath around certain nerve fibers Synonymsmultiple sclerosisMSdisseminated sclerosisdisseminated multiple sclerosis Related words Broader terms sclerosisdegenerative disorder Part of demyelination WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.