myosis myo·sis uncommon noun 1. an acute infectious disease occurring in epidemic form and featuring paroxysms of pain (usually in the chest) Synonymsepidemic pleurodyniaepidemic myalgiadiaphragmatic pleurisyBornholm disease 2. reflex contraction of the sphincter muscle of the iris in response to a bright light (or certain drugs) causing the pupil to become smaller Synonymslight reflexpupillary reflexmiosis Related words Broader terms reflexepidemic disease WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.