Paleo-Indian culture pa·leoin·dian·culture uncommon noun 1. the prehistoric culture of the earliest human inhabitants of North America and South America SynonymsPaleo-American culturePaleo-Amerind culturePaleo-Indian culture Related words Broader terms culture Narrower terms Clovis cultureFolsom culture WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.