peptic ulcer pep·ti·cul·cer uncommon noun 1. an ulcer of the mucous membrane lining of the alimentary tract Synonymspeptic ulcerpeptic ulceration Related words Word family peptic ulceration Broader terms ulcer Narrower terms duodenal ulcergastric ulcer WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.