Raffaello Sanzio raf·fael·lo·sanzio uncommon noun 1. Italian painter whose many paintings exemplify the ideals of the High Renaissance (1483-1520) SynonymsRaphaelRaffaello SantiRaffaello Sanzio Related words Broader terms old master WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.