Santa Cruz san·tac·ruz US/ˈsæntʌˈkruz/ uncommon noun 1. a town in western California on Monterey Bay; a tourist center SynonymsSanta Cruz 2. a city in central Bolivia SynonymsSanta Cruz Related words Word family Santa Cruz cypress Broader terms citytown Parts BoliviaCalifornia WordNet 2.1 (Princeton University). CMU Pronouncing Dictionary. WordNet 2.1 Copyright Princeton University. All rights reserved.