sickle cell sick·le·cell uncommon noun 1. an abnormal red blood cell that has a crescent shape and an abnormal form of hemoglobin Synonymssickle cell Related words Word family sickle-cell anaemiasickle-cell anemiasickle-cell disease Broader terms red blood cell WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.