simple sugar simp·le·su·gar uncommon noun 1. a sugar (like sucrose or fructose) that does not hydrolyse to give other sugars; the simplest group of carbohydrates Synonymsmonosaccharidemonosaccharosesimple sugar Related words Broader terms carbohydrate Narrower terms triosetetrosepentosehexosealdoseketose WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.