Spanish Guinea spa·nish·gui·nea uncommon noun 1. a country of west central Africa (including islands in the Gulf of Guinea); became independent from Spain in 1968 SynonymsEquatorial GuineaRepublic of Equitorial GuineaSpanish Guinea Related words Broader terms African country Parts Africa Part of Bioko WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.