spotted Joe-Pye weed spot·ted·joe·pyeweed uncommon noun 1. North American herb having whorled leaves and terminal clusters of small pinkish or purple flower heads SynonymsJoe-Pye weedspotted Joe-Pye weedEupatorium maculatum Related words Broader terms herb Parts Eupatorium WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.