thrombolytic agent throm·bo·ly·ticagent uncommon noun 1. a kind of pharmaceutical that can break up clots blocking the flow of blood to the heart muscle Synonymsthrombolyticthrombolytic agentclot buster Related words Broader terms pharmaceutical Narrower terms tissue plasminogen activator WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.