tranquilliser tran·quil·li·ser uncommon uk noun 1. a drug used to reduce stress or tension without reducing mental clarity Synonymstranquilizertranquillizerantianxiety agentataractic drugataractic agentataractic Related words Word family tranquillisetranquillizetranquilize Broader terms psychotropic agentsedative-hypnotic Narrower terms major tranquilizerminor tranquilizer WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.