tranquillize tran·quil·lize uncommon verb 1. make calm or still “quiet the dragons of worry and fear” Synonymscalmcalm downquiettranquilizetranquillisequietenlullstill Antonymsagitate 2. cause to be calm or quiet as by administering a sedative to “The patient must be sedated before the operation” Synonymssedatecalmtranquilizetranquillise Antonymsstimulate Related words Word family tranquillisertranquillizertranquilizercalmsedationstilllullquiet Broader terms affectcomfort Narrower terms hypnotizelullcomposepacifyreassure WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.