VLDL uncommon noun 1. large lipoproteins rich in triglycerides; VLDLs circulate through the blood giving up their triglycerides to fat and muscle tissue until the VLDL remnants are modified and converted into LDL Synonymsvery low density lipoprotein Related words Broader terms lipoprotein WordNet 2.1 (Princeton University). WordNet 2.1 Copyright Princeton University. All rights reserved.