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Methotrexate, a folate analogue, was initially synthesized in the 1940s to serve as a dihydrofolate reductase (DHFR) inhibitor. It has a core structure comprised of an amino group (NH2) associated with a totally oxidized pteridine ring.
Linker design for ADCs is highly dependent on the biolology of the target cells, the characteristics of the antibody, and the structure of the drug molecule. Selection of the optimal linker is achieved through efficacy and toxicity assessments for ea
Peptide linkers belong to protease-sensitivity linkers (also called enzymatically cleavable linkers) that have gained significant attention in ADC development due to their superior plasma stability and controled payload release mechanism.
Vaccine technology has evolved significantly in the last decade. To accelerate response time to emerging threats, develop vaccines against difficult targets, Creative Biolabs offers a full range of vaccine design and production services.
pH-sensitive linkers (acid-labile linkers), are a class of chemically cleavable linkers that were first used in early ADC developments. Hydrazonesand cis-Aconityl is among the most widely used pH-sensitive linkers. A cis-aconityl linkage is offen use
Infectious diseases cause an overwhelming number of deaths around the world and their clinical management is often hampered by the emergence of multidrug resistant strains. Therefore, prevention through vaccination is currently the best course of act
Methotrexate, a folate analogue, was initially synthesized in the 1940s to serve as a dihydrofolate reductase (DHFR) inhibitor. It has a core structure comprised of an amino group (NH2) associated with a totally oxidized pteridine ring.
Well development of a vaccine project requires an experienced partner who understands the unique complexity presented by this important research area.
Ipatasertib, also known as GDC-0068, is a strong ATP-competitive pan-AKT inhibitor. It was initially derived during the screening and optimization process of a series of 6,7-dihydro-5H-cyclopenta[d]pyrimidine compounds.
ADCs are next-generation precision medicines that target specific surface antigens and fight diseases by delivering cytotoxic payload drugs into the antigen-bearing cells. ADCs are trending in immunotherapy and are believed to have high potential and
In ADC development, lysine-based conjugation is one of the most widely used non-specific conjugation strategies. This conjugation occurs on reactive amine side chains of lysine residues due to their good nucleophilicity.
Infectious diseases cause an overwhelming number of deaths around the world and their clinical management is often hampered by the emergence of multidrug resistant strains.
Maytansine and its derivatives (named as maytansinoids in general) are members of the ansamycins superfamily and contains a 19-member macrocyclic lactams attached to a chlorinated benzene.
Peptide linkers belong to protease-sensitivity linkers (also called enzymatically cleavable linkers) that have gained significant attention in ADC development due to their superior plasma stability and controled payload release mechanism.
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