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Percocet Prescription Online Percocet is a combination medication that includes oxycodone (an opioid) and acetaminophen. It is used to relieve moderate to severe pain, particularly after surgery or injury. The dual-action formula works by altering pain perception in the brain while reducing inflammation. Because Percocet contains an opioid component, it carries a risk of dependence and misuse. It should be used only as prescribed and for the duration recommended by a healthcare provider. Patients should avoid exceeding the prescribed dose to prevent serious complications. Side effects may include nausea, dizziness, constipation, and drowsiness. Close medical supervision is essential to ensure safe and effective pain management.