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Glutamate is an essential excitatory neurotransmitter regulating brain functions. Excitatory amino acid transporter (EAAT)-2 is one of the major glutamate transporters expressed predominantly in astroglial cells and is responsible for 90% of total gl
Telocinobufagin is one of anti-hepatoma constituent in Venenum Bufonis.
At BOC Sciences, custom bioconjugation reagents are manufactured under a strict quality control process to assure customers' complete satisfaction. Just contact [email protected] for more information.
Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1.It is currently approved for the treatment of rheumatoid arthritis (RA) in the United States.
Hsp90 uses a host of cochaperones which not only regulate the ATPase activity and conformational dynamics but which also mediate interactions with Hsp90 client proteins.
Description: Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. Molecular Formula C9H15N5O
Molecular Weight 209.25
Pre-formulation studies in combination with analytical methods are critical to identifying the best formulation strategy for a compound. Certain candidates present specific challenges such as poor solubility, low bioavailability and/or permeability.
?-secretase maturation and its hardcore function in amyloidogenic pathway and notch pathway will be discussed below. Also, some inhibitors of ?-secretase, which appeal to the scientists, are expected to be potential drugs of AD and cancers induced
Cell adhesion molecules (CAMs) are molecules involved in the interaction between cells and extracellular matrix. CAM refers to the adhesion between cells, which is a form of information exchange between cells. CAM is a transmembrane glycoprotein.
The Hh signaling pathway is a highly compliant signaling pathway that plays an important role in many aspects. Especially, it plays a vital role in embryonic development and growth regulation, being morphogens, mitogens and organ development.
The active form of AMPK, i.e. phosphorylated AMP-activated protein kinase (p-AMPK), can down regulate the energy consuming process as well as increase adenosine triphosphate (ATP) generation through stimulating ATP-producing catabolic pathways.
cell immunoglobulin and mucin domain 3 (TIM3) is a member of Tim family, which consists of 301 amino acids. The common structure of TIM3 molecules includes: variable region of N-terminal immunoglobulin, mucin domain, transmembrane region and intracel
DNA encoded library (DEL) is a new screening platform commonly used to discover small-molecules that interfere with the activity of pharmaceutically relevant proteins. DNA-encoded chemical libraries are hybrid-type collections of combinatorial organi
1,2,3,4,5,6,7,8-Octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline is a useful synthetic compound.
Omapatrilat, an octahydropyridothiazepine derivative, has been found to be an ACE inhibitor as well as an endopeptidase inhibitor and was once studied in heart failure and hypertension.
Also known as desoxyepothilone B, epothilone D binds to tubulin and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis, cellular proliferation, and cell motility.
Mertansine, the cytotoxic component in antibody-drug conjugates, attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker or SMCC (4-(3-mercapto-2,5-dioxo-1 pyrrolidinylmethyl)-cyl
Dopamine Reuptake Inhibitors (DRIs) are drugs that function by preventing the reuptake of the neurotransmitter dopamine. The fact that they prevent dopamine reuptake leads to increased concentrations of dopamine between synapses.
Pilaralisib is a Class 1 phosphatidylinositol 3 kinase (PI3K) family inhibitor. It is an orally bioavailable small molecule, targeting the class I PI3K family of lipid kinases. It is a pyrimidine derivatives compound discovered by Exelixis Inc.
Fatty acid amide hydrolase or FAAH (oleamide hydrolase, anandamide amidohydrolase) is a member of the serine hydrolase family of enzymes. FAAH is an integral membrane hydrolase with a single N-terminal transmembrane domain.
The maturing petroleum-based chemical industry, the pressures of environmental constraints and the explosive development of biotechnology have increased the interest in catalysis in enzymology. Just contact [email protected] for more information.
Ecamsule protect the skin from sunburn and erythema. It causes serious eye damage, so please wear protective gloves/protective clothing/eye protection/face protection.
Nuclear factor-?B (NF-?B) is a class of transcription factors that are ubiquitous in various cell types in living organisms. In 1986, Sen and Baltimoer first detected a nuclear protein factor that specifically bound to the immunoglobulin ? light chai
The p38 mitogen-activated protein kinase (p38MAPK) signaling pathway is a member of the mitogen-activated protein kinase (MAPK) family and is composed of MAPK kinase kinase, MAPK kinase and p38MAPK.
Epidermal growth factor (EGF) was first discovered in newborn rats in 1962. After about 20 years, the human epidermal growth factor receptor (EGFR) was isolated and purified. As research progresses, EGFR and its downstream pathways are constantly und
Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamins are principally involved in the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartm
Calcium-sensing receptor (CaSR), a member of family C of the G protein-coupled receptors, is expressed most abundantly in the parathyroid glands and kidney. It plays key role in these two organs because it senses changes in extracellular calcium.
Vitamin D2 and Impurities
Catalog Product Name CAS Number
Ergocalciferol Glucuronide
Ergocalciferol Sulfate
21343-40-8 25-Hydroxy-Ergocalciferol (25-(OH)-Vitamin D2) 21343-40-8
50-14-6 Vitamin D2 (Ergocalciferol) 50-14-6
BOC Sciences provides wide range of services such as custom radioisotope and stable isotope labeling to support your regulatory, development or research programs.
Calcitriol and Impurities
Catalog Product Name CAS Number
103656-40-2 24-Homo Calcitriol 103656-40-2
B0504-485047 5,6-trans Calcitriol 73837-24-8
B0504-485045 pre-Calcitriol PTAD Adduct 86307-44-0
B0504-467988 Epi-Calcitriol 66791-71-7
The main types of immunotherapy can be broadly subdivided into non-antigen-specific and antigen-specific categories. Non-antigen-specific strategies include nonspecific immune stimulation and Immune checkpoint inhibitors,just contact [email protected]
TP-0903 is a potent anti-cancer agent targeting the AXL receptor tyrosine kinase that has demonstrated profound activity in several cell-based and animal models of cancer.
BOC Sciences manufactures thousands of pharmaceutical impurities, degradations, metabolites of active pharmaceutical ingredients, and excipients in accordance with the guidelines and limits described in the international pharmacopeia monographs for m
Nutritional supplement; dietary supplements; health food additives; sport nutrition; sport supplements; bodybuilding supplement; pharmaceutical raw material; As a building block of selenoproteins.
Akt, or protein kinase B (PKB), is a Ser/Thr protein kinase that phosphorylates a variety of protein substrates to regulate numerous cellular functions. Such as protein synthesis, metabolism, transcription, cellular proliferation, cellular differenti
Cyclosporine A - CAS 59865-13-3
Catalog number: 59865-13-3 Category: APIs
Molecular Formula C62H111N11 O12
Molecular Weight 1202.61
COA Inquire
Catalog Product Name CAS Number
B0503-467984 Calcipotriol Impurity 1 112849-47-5
147657-22-5 Calcipotriol (Calcipotriene) Monohydrate 147657-22-5
B0503-467982 Calcipotriol Impurity F 112875-61-3
B0503-467980 Calcipotriol Impurity D 112827-99-3
RO4929097, a small-molecule inhibitor of ? secretase (IC50= 4 nM, EC50= 5 nM), inhibits cellular processing of A?40 (EC50= 14 nM) and Notch(EC50= 5 nM). In vitro: Decreases the amount of A? peptides secreted into the culture medium in HEK293 cells (E
mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. mTOR also functions as a tyrosine protein kinase that promotes the acti
Apoptosis refers to the autonomous, orderly programmed cell death of cells controlled by genes to maintain homeostasis, and plays an important role in maintaining intracellular homeostasis. There are three main apoptotic pathways.
Based on the type of cargo delivery, there are three types of autophagy systems in mammals. They are macroautophagy (autophagy), microautophagy, and chaperone-mediated autophagy.
VISTA also called Dies1 differentiation of embryonic stems cells 1 (Dies1), PD-1 homologous protein (PD-1H), belongs to the immunoglobulin family. The extracellular domain of VISTA is homologous to PD-L1. Human VISTA is mainly expressed in CD4+ cells
Various labeling techniques are developed in BOC Sciences such as enzymatic labeling, protein labeling, genetic labeling and quantum dot are widely utilized to meet our customers' need. Just contact [email protected] for more information.
Chiral synthesis (enantioselective synthesis, also called asymmetric synthesis) is the synthesis of a compound by a method that favors the formation of a specific enantiomer or diastereomer. It is a key process in modern chemistry and is particularly
Teriparatidet is an effective anabolic (i.e., bone growing) agent used in the treatment of some forms of osteoporosis. It is also occasionally used off-label to speed fracture healing.
The first small molecule inhibitor of JNK to enter clinical trials was CC-401 (Celgene). A corporate press release dated February 5, 2003 stated CC-401, successfully completed a Phase I, double-blind, placebo controlled, ascending single intravenou
The two most common naturally occurring amino acids that are used to attach the linker drug to the antibody are cysteines and lysines.
The screening libraries at BOC Sciences are made up of twenty-one libraries that can be used for drug discovery, laboratory drug screening, drug target identification, and other drug related applications. Each library can be screened individually or
PI3K (Phosphatidylinositol-4,5-bisphosphate 3-kinase) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
Prepared by the two natural products, oxidation and oximation, of an 80:20 ratio of milbemycin A3 and A,Milbemycin oxime is a semi-synthetic macrocyclic lactone.
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