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The main types of immunotherapy can be broadly subdivided into non-antigen-specific and antigen-specific categories. Non-antigen-specific strategies include nonspecific immune stimulation and Immune checkpoint inhibitors,just contact [email protected]
TP-0903 is a potent anti-cancer agent targeting the AXL receptor tyrosine kinase that has demonstrated profound activity in several cell-based and animal models of cancer.
BOC Sciences manufactures thousands of pharmaceutical impurities, degradations, metabolites of active pharmaceutical ingredients, and excipients in accordance with the guidelines and limits described in the international pharmacopeia monographs for m
Nutritional supplement; dietary supplements; health food additives; sport nutrition; sport supplements; bodybuilding supplement; pharmaceutical raw material; As a building block of selenoproteins.
Akt, or protein kinase B (PKB), is a Ser/Thr protein kinase that phosphorylates a variety of protein substrates to regulate numerous cellular functions. Such as protein synthesis, metabolism, transcription, cellular proliferation, cellular differenti
Cyclosporine A - CAS 59865-13-3
Catalog number: 59865-13-3 Category: APIs
Molecular Formula C62H111N11 O12
Molecular Weight 1202.61
COA Inquire
Catalog Product Name CAS Number
B0503-467984 Calcipotriol Impurity 1 112849-47-5
147657-22-5 Calcipotriol (Calcipotriene) Monohydrate 147657-22-5
B0503-467982 Calcipotriol Impurity F 112875-61-3
B0503-467980 Calcipotriol Impurity D 112827-99-3
RO4929097, a small-molecule inhibitor of ? secretase (IC50= 4 nM, EC50= 5 nM), inhibits cellular processing of A?40 (EC50= 14 nM) and Notch(EC50= 5 nM). In vitro: Decreases the amount of A? peptides secreted into the culture medium in HEK293 cells (E
mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. mTOR also functions as a tyrosine protein kinase that promotes the acti
Apoptosis refers to the autonomous, orderly programmed cell death of cells controlled by genes to maintain homeostasis, and plays an important role in maintaining intracellular homeostasis. There are three main apoptotic pathways.
Based on the type of cargo delivery, there are three types of autophagy systems in mammals. They are macroautophagy (autophagy), microautophagy, and chaperone-mediated autophagy.
VISTA also called Dies1 differentiation of embryonic stems cells 1 (Dies1), PD-1 homologous protein (PD-1H), belongs to the immunoglobulin family. The extracellular domain of VISTA is homologous to PD-L1. Human VISTA is mainly expressed in CD4+ cells
Various labeling techniques are developed in BOC Sciences such as enzymatic labeling, protein labeling, genetic labeling and quantum dot are widely utilized to meet our customers' need. Just contact [email protected] for more information.
Chiral synthesis (enantioselective synthesis, also called asymmetric synthesis) is the synthesis of a compound by a method that favors the formation of a specific enantiomer or diastereomer. It is a key process in modern chemistry and is particularly
Teriparatidet is an effective anabolic (i.e., bone growing) agent used in the treatment of some forms of osteoporosis. It is also occasionally used off-label to speed fracture healing.
The first small molecule inhibitor of JNK to enter clinical trials was CC-401 (Celgene). A corporate press release dated February 5, 2003 stated CC-401, successfully completed a Phase I, double-blind, placebo controlled, ascending single intravenou
The two most common naturally occurring amino acids that are used to attach the linker drug to the antibody are cysteines and lysines.
The screening libraries at BOC Sciences are made up of twenty-one libraries that can be used for drug discovery, laboratory drug screening, drug target identification, and other drug related applications. Each library can be screened individually or
PI3K (Phosphatidylinositol-4,5-bisphosphate 3-kinase) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
Prepared by the two natural products, oxidation and oximation, of an 80:20 ratio of milbemycin A3 and A,Milbemycin oxime is a semi-synthetic macrocyclic lactone.
Metabolites are the products of enzyme-catalyzed reactions that occur naturally within cells. The term metabolite is usually used to describe small molecules, while broader application is often practiced.
The JNK MAPK pathway is predominantly activated by stress stimuli and plays important roles in development, apoptosis, cell growth, inflammatory, and immune responses. Just contact [email protected] for more information.
Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins).
The p53 gene is an important tumor suppressor gene, and its encoded p53 protein plays a key role in cell cycle regulation, DNA repair, and induction of apoptosis. Mutation of the p53 gene is one of the important factors in tumorigenesis.
ERK protein kinase was isolated and identified in the early 1990s as a signal transduction protein that transmits mitogen signals. It is often found in the cytosol and is rapidly translocated into the nucleus of the cell when it is activated by mitog
Histone deacetylases (HDACs), that may be called protein deacetylases (PDAC) as some of their targets are non-histone proteins, are a family of eleven zinc-dependent enzymes that have gained major interest as therapeutic targets, mainly in cancer res
KIR, short for Killer-cell Immunoglobulin-like Receptor, is a receptor mainly expressed on the surface of natural killer (NK) cells and some T cells, which can recognize the major histocompatibility complex class I ?MHC-I? on the surface of target.
Calcitriol and Impurities
Catalog Product Name CAS Number
103656-40-2 24-Homo Calcitriol 103656-40-2
B0504-485047 5,6-trans Calcitriol 73837-24-8
B0504-485045 pre-Calcitriol PTAD Adduct 86307-44-0
B0504-467988 Epi-Calcitriol 66791-71-7
Vitamin D deficiency results in rickets, osteomalacia, osteoporosis, and is associated with multiple diseases including cancer, Alzheimer's disease, rheumatoid arthritis, diabetes, hypertension, glucose intolerance, and multiple sclerosis.
Peficitinib, also known as ASP015K and JNJ-54781532, is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats. ASP015K may have potential use in prevention of rejection in solid organ transplanta
Several groups hypothesized that it may be necessary to construct ADCs with drugs of much higher molar potencies than conventional chemotherapeutics to achieve therapeutically effective levels of active drug within tumors in patients.
MCC950, also called as CP-456773 or CRID3, is a small molecule that selectively inhibits activation of NLRP3 but does not inhibit NLRC4, AIM2, TLR2 signaling, or priming of NLRP3. MCC950 can be used to treat inflammatory diseases.
Bombesin receptors (nomenclature recommended by the NC-IUPHAR Subcommittee on bombesin receptors) are activated by the endogenous ligands gastrin-releasing peptide (GRP, P07492) (GRP), neuromedin B (NMB, P08949) (NMB) and GRP-(18-27) (GRP, P07492)
Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic acti
There are three recognised classes of carbonic anhydrase enzymes, alpha, beta and gamma, which have no significant sequence identity, and have structurally distinct overall folds. Yet, despite their structural differences.
The Ras superfamily of small GTPases is composed of more than 150 members, which share a conserved structure and biochemical properties, acting as binary molecular switches turned on by binding GTP and off by hydrolyzing GTP to GDP.
Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane. It was first described as peripheral benzodiazepine receptor (PBR), a secondary binding site for diazepam, but subsequent research has found the recept
The PI3K/Akt signaling pathway is an intracellular signaling pathway that plays an important role in apoptosis, malignancy, tumor progression, metastasis, and radiation therapy. It regulates abnormalities in cancer patients caused by mutations.
The G protein-coupled receptor (GPCR) family is the largest family of membrane proteins in eukaryotes. It encodes at least 800 human genes. But endogenous ligands of more than 140 GPCRs have not been determined. Such GPCRs are referred to as orphan G
Elastase is an enzyme that digests and degrades a number of proteins including elastin, an elastic substance in the lungs and some other organs that supports their structural framework. Elastase is specifically inhibited by alpha-1 antitrypsin.
Superparamagnetic iron oxide microbeads have broad applications in biomedicine, such as magnetic cell isolation and biomolecules purification, magnetic resonance imaging of diseased tissues, magnetic immunoassay, targeted delivery of drugs and antige
Our scientific team has established virtual compound database for different client-based projects with more than 2 million unique compounds, including ZINC, MDDR, ACD, NCI, etc. Just contact [email protected] for more information.
Small-molecule modulators are a well-established class of potential useful drugs. Our products are included in all kinds of fields of Medical and Pharmaceutical research, such as Neurological Disease, Cancer, Metabolic Disease and so on.
PD-1, short for Programmed Death 1 (PD-1) receptor, a member of the B7 protein superfamily, is overexpressed on certain tumor cell types and on various tumor-infiltrating immune cells, and has two ligands, PD-L1 and PD-L2. An advantage of targeting P
Nivolumab, marketed as Opdivo, is a humanized IgG4 anti-PD-1 monoclonal antibody used to treat cancer. Nivolumab works as a checkpoint inhibitor, blocking a signal that would have prevented activated T cells from attacking the cancer, thus allowing.
Nepicastat hydrochloride (SYN117, RS-25560-197) is an inhibitor of dopamine beta-hydroxylase that catalyzes the conversion of dopamine to norepinephrine.
IDO inhibitors may help to promote an enhanced immune response against the tumor by blocking the IDO enzyme which reduces the depletion of tryptophan.
B7-H3 is a type I transmembrane protein belonging to the B7 family of co-stimulatory proteins. B7-H3 is mostly expressed on professional APCs including B cells, macrophages, and dendritic cells at low levels. It is detected on various human and murin
Customers are also welcome to provide literature methods or their own synthetic routes in which all relevant information such as reaction time, solvent, temperature, analytic data, purification method, yield, etc. is detailed.
Paricalcitol and Impurities
Catalog Product Name CAS Number
Paricalcitol Impurity 2
B0075-478591 Paricalcitol Impurity 1 1884139-61-0
Paricalcitol Sulfate
B0075-460980 Paricalcitol Impurity 4 95716-68-0
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